Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

• Main Authors: Aroonwan Lam-ubol, Alison Lea Fitzgerald, Arnat Ritdej, Tawaree Phonyiam, Hui Zhang, Myers, Jeffrey N., Peng Huang, Dunyaporn Trachootham
• Other Authors: Mahidol University. Institute of Nutrition
• Format: Article
• Language: English
• Published: 2018
• Subjects: PEITC; Oral cancer prevention; Oral cancer; β-phenylethyl isothiocyanate
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25197
• Institution: Mahidol University

High doses of β-phenylethyl isothiocyanate (PEITC), a phytochemical in cruciferous vegetables, are not feasible for consumption due to a strong mouth-tingling effect. This study investigated the anti-cancer effect of PEITC at sensory acceptable doses. In vitro, PEITC was selectively toxic to oral...