Effects of temperature and humidity on the physical properties of piroxicam tablets
The authors studied piroxicam tablets containing various proportions of filler (lactose or mannitol) after storage for 12 weeks of 40 °C and 52% relative humidity (RH) and at 40°C and 96% RH. The tablets were prepared by wet granulation using providone as a binder. They were compressed at forces of...
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th-mahidol.253422018-09-07T16:02:49Z Effects of temperature and humidity on the physical properties of piroxicam tablets Narong Sarisuta Tassanee Thamsakdakorn Somboon Jateteela Mahidol University Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics The authors studied piroxicam tablets containing various proportions of filler (lactose or mannitol) after storage for 12 weeks of 40 °C and 52% relative humidity (RH) and at 40°C and 96% RH. The tablets were prepared by wet granulation using providone as a binder. They were compressed at forces of 500-600 kg for hardness values of 6-7 kg and stored in a controlled environmental chamber. Physical properties of the tablets such as weight, thickness, hardness, loss on drying, disintegration, and dissolution were assessed every 2 weeks. This article discusses the methods used to conduct the studies and the results. 2018-09-07T08:48:28Z 2018-09-07T08:48:28Z 1999-04-28 Article Pharmaceutical Technology. Vol.23, No.4 (1999) 01478087 2-s2.0-0033008652 https://repository.li.mahidol.ac.th/handle/123456789/25342 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033008652&origin=inward |
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Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics Narong Sarisuta Tassanee Thamsakdakorn Somboon Jateteela Effects of temperature and humidity on the physical properties of piroxicam tablets |
| description |
The authors studied piroxicam tablets containing various proportions of filler (lactose or mannitol) after storage for 12 weeks of 40 °C and 52% relative humidity (RH) and at 40°C and 96% RH. The tablets were prepared by wet granulation using providone as a binder. They were compressed at forces of 500-600 kg for hardness values of 6-7 kg and stored in a controlled environmental chamber. Physical properties of the tablets such as weight, thickness, hardness, loss on drying, disintegration, and dissolution were assessed every 2 weeks. This article discusses the methods used to conduct the studies and the results. |
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Mahidol University |
| author_facet |
Mahidol University Narong Sarisuta Tassanee Thamsakdakorn Somboon Jateteela |
| format |
Article |
| author |
Narong Sarisuta Tassanee Thamsakdakorn Somboon Jateteela |
| author_sort |
Narong Sarisuta |
| title |
Effects of temperature and humidity on the physical properties of piroxicam tablets |
| title_short |
Effects of temperature and humidity on the physical properties of piroxicam tablets |
| title_full |
Effects of temperature and humidity on the physical properties of piroxicam tablets |
| title_fullStr |
Effects of temperature and humidity on the physical properties of piroxicam tablets |
| title_full_unstemmed |
Effects of temperature and humidity on the physical properties of piroxicam tablets |
| title_sort |
effects of temperature and humidity on the physical properties of piroxicam tablets |
| publishDate |
2018 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/25342 |
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1763488035899441152 |