Allelic recombination and linkage disequilibrium within Msp-1 of Plasmodium falciparum, the malignant human malaria parasite

• Main Authors: Naoko Sakihama, Masatsugu Kimura, Kenji Hirayama, Tozo Kanda, Kesara Na-Bangchang, Somchai Jongwutiwes, David Conway, Kazuyuki Tanabe
• Other Authors: Osaka Institute of Technology
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25345
• Institution: Mahidol University

The C-terminal, cysteine-rich 19 kDa domain of merozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a target of the host's humoral immunity and thus a malaria vaccine candidate. Although variation in the 19 kDa domain is limited among parasite isolates, tertiary structure-dependent i...