Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria
The pharmacokinetics of benflumetol as a fixed combination, artemether-benflumetol (CGP 56697), following three regimens [regimen A: four tablets at 0, 8, 24 and 48 h (320 mg artemether, 1920 mg benflumetol); regimen B: two tablets at 0, 8, 24 and 48 h (160 mg artemether; 960 mg benflumetol); regime...
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th-mahidol.257772018-09-07T16:02:45Z Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria K. Na-Bangchang J. Karbwang U. Tasanor A. Thanavibul E. Farkad R. Mull Mahidol University Novartis International AG Thammasat University Pharmacology, Toxicology and Pharmaceutics The pharmacokinetics of benflumetol as a fixed combination, artemether-benflumetol (CGP 56697), following three regimens [regimen A: four tablets at 0, 8, 24 and 48 h (320 mg artemether, 1920 mg benflumetol); regimen B: two tablets at 0, 8, 24 and 48 h (160 mg artemether; 960 mg benflumetol); regimen C: four tablets at 0, 8 and 24 h (240 mg artemether; 1440 mg benflumetol)] were investigated in 39 patients with acute uncomplicated falciparum malaria. All patients showed a rapid initial response with a median parasite clearance time of 40, 41 and 39.5 h and a fever clearance time of 27.8, 32 and 24.5 h for regimens A, B and C, respectively. In nine patients (two, four and three patients in regimens A, B and C, respectively), however parasitemia reappeared in the peripheral blood smear between days 9 and 23. The pharmacokinetics of benflumetol were highly variable with coefficients of variation in pharmacokinetic parameters ranging from 14.9% to 144%. Absorption and elimination of benflumetol were relatively slow. Median C(max) per dose (first dose) was significantly higher in regimen B (6.29 ng/ml/mg dose) than in regimen A (2.6 ng/ml/mg dose) and regimen C (3.06 ng/ml/mg dose). Mean t(1/2z) in regimen C (2.65 h) was significantly shorter than in regimen A (4.5 h) and regimen B (3.89 h). In patients on regimens A and B who showed a sensitive response, plasma concentrations of benflumetol were significantly higher than in those with treatment failure. 2018-09-07T09:02:45Z 2018-09-07T09:02:45Z 1999-12-01 Article International Journal of Clinical Pharmacology Research. Vol.19, No.2 (1999), 41-46 02511649 2-s2.0-0033402421 https://repository.li.mahidol.ac.th/handle/123456789/25777 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033402421&origin=inward |
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Pharmacology, Toxicology and Pharmaceutics K. Na-Bangchang J. Karbwang U. Tasanor A. Thanavibul E. Farkad R. Mull Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
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The pharmacokinetics of benflumetol as a fixed combination, artemether-benflumetol (CGP 56697), following three regimens [regimen A: four tablets at 0, 8, 24 and 48 h (320 mg artemether, 1920 mg benflumetol); regimen B: two tablets at 0, 8, 24 and 48 h (160 mg artemether; 960 mg benflumetol); regimen C: four tablets at 0, 8 and 24 h (240 mg artemether; 1440 mg benflumetol)] were investigated in 39 patients with acute uncomplicated falciparum malaria. All patients showed a rapid initial response with a median parasite clearance time of 40, 41 and 39.5 h and a fever clearance time of 27.8, 32 and 24.5 h for regimens A, B and C, respectively. In nine patients (two, four and three patients in regimens A, B and C, respectively), however parasitemia reappeared in the peripheral blood smear between days 9 and 23. The pharmacokinetics of benflumetol were highly variable with coefficients of variation in pharmacokinetic parameters ranging from 14.9% to 144%. Absorption and elimination of benflumetol were relatively slow. Median C(max) per dose (first dose) was significantly higher in regimen B (6.29 ng/ml/mg dose) than in regimen A (2.6 ng/ml/mg dose) and regimen C (3.06 ng/ml/mg dose). Mean t(1/2z) in regimen C (2.65 h) was significantly shorter than in regimen A (4.5 h) and regimen B (3.89 h). In patients on regimens A and B who showed a sensitive response, plasma concentrations of benflumetol were significantly higher than in those with treatment failure. |
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Mahidol University |
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Mahidol University K. Na-Bangchang J. Karbwang U. Tasanor A. Thanavibul E. Farkad R. Mull |
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K. Na-Bangchang J. Karbwang U. Tasanor A. Thanavibul E. Farkad R. Mull |
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K. Na-Bangchang |
title |
Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
title_short |
Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
title_full |
Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
title_fullStr |
Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
title_full_unstemmed |
Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria |
title_sort |
pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (cgp 56697) in thai patients with uncomplicated falciparum malaria |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/25777 |
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1763490504621686784 |