Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5' noncoding region and nonstructural proteins 1 and 3

Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5' noncoding region and nonstructural proteins 1 and 3

The genome of a candidate dengue type 2 (DEN-2) vaccine virus, strain PDK-53, differs from its DEN-2 16681 parent by nine nucleotides. Using infectious cDNA clones, we constructed 18 recombinant 16681/PDK-53 viruses to analyze four 16681-to-PDK-53 mutations, including 5' noncoding region (5...

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Bibliographic Details
Main Authors: Siritorn Butrapet, Claire Y.H. Huang, Dennis J. Pierro, Natth Bhamarapravati, Duane J. Gubler, Richard M. Kinney
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/25804
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/25804

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