Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction

Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. To assess whether EBV DNA detection by polymerase chain reaction (PCR) or presence of specific serum antibody to viral capsid antigen (VCA) was a better marker for screening NPC, nasopharyngeal tissues and...

Full description

Saved in:
Bibliographic Details
Main Authors: W. Kantakamalakul, C. Chongkolwatana, P. Naksawat, S. Muangsomboon, S. Sukpanichnant, S. Chongvisal, C. Metheetrairat, U. Kositanont, P. Puthavathana
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/25956
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.25956
record_format dspace
spelling th-mahidol.259562018-09-07T16:15:21Z Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction W. Kantakamalakul C. Chongkolwatana P. Naksawat S. Muangsomboon S. Sukpanichnant S. Chongvisal C. Metheetrairat U. Kositanont P. Puthavathana Mahidol University Immunology and Microbiology Medicine Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. To assess whether EBV DNA detection by polymerase chain reaction (PCR) or presence of specific serum antibody to viral capsid antigen (VCA) was a better marker for screening NPC, nasopharyngeal tissues and blood samples from 58 NPC patients and 24 non-NPC patients (23 with laryngotracheal stenosis and 1 with chronic tonsillitis) were tested for the presence of EBV DNA and serum specific VCA antibodies, respectively. EBV DNA was detected in 56 (96.5%) of NPC patients and 15 (62.5%) of non-NPC controls, with predominantly EBV type A in both groups. On the other hand, specific VCA IgA antibody was detected in the majority of NPC patients: 52 (89.7%) while only 4 (16.7%) were detected in non-NPC controls. Therefore, specific VCA IgA antibody may serve as a better marker for screening NPC than EBV DNA detected by PCR. 2018-09-07T09:11:13Z 2018-09-07T09:11:13Z 2000-12-01 Article Asian Pacific Journal of Allergy and Immunology. Vol.18, No.4 (2000), 221-226 0125877X 2-s2.0-0034462072 https://repository.li.mahidol.ac.th/handle/123456789/25956 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034462072&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
W. Kantakamalakul
C. Chongkolwatana
P. Naksawat
S. Muangsomboon
S. Sukpanichnant
S. Chongvisal
C. Metheetrairat
U. Kositanont
P. Puthavathana
Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
description Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. To assess whether EBV DNA detection by polymerase chain reaction (PCR) or presence of specific serum antibody to viral capsid antigen (VCA) was a better marker for screening NPC, nasopharyngeal tissues and blood samples from 58 NPC patients and 24 non-NPC patients (23 with laryngotracheal stenosis and 1 with chronic tonsillitis) were tested for the presence of EBV DNA and serum specific VCA antibodies, respectively. EBV DNA was detected in 56 (96.5%) of NPC patients and 15 (62.5%) of non-NPC controls, with predominantly EBV type A in both groups. On the other hand, specific VCA IgA antibody was detected in the majority of NPC patients: 52 (89.7%) while only 4 (16.7%) were detected in non-NPC controls. Therefore, specific VCA IgA antibody may serve as a better marker for screening NPC than EBV DNA detected by PCR.
author2 Mahidol University
author_facet Mahidol University
W. Kantakamalakul
C. Chongkolwatana
P. Naksawat
S. Muangsomboon
S. Sukpanichnant
S. Chongvisal
C. Metheetrairat
U. Kositanont
P. Puthavathana
format Article
author W. Kantakamalakul
C. Chongkolwatana
P. Naksawat
S. Muangsomboon
S. Sukpanichnant
S. Chongvisal
C. Metheetrairat
U. Kositanont
P. Puthavathana
author_sort W. Kantakamalakul
title Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
title_short Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
title_full Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
title_fullStr Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
title_full_unstemmed Specific IgA antibody to Epstein-Barr viral capsid antigen: A better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction
title_sort specific iga antibody to epstein-barr viral capsid antigen: a better marker for screening nasopharyngeal carcinoma than ebv-dna detection by polymerase chain reaction
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/25956
_version_ 1763494408933605376