Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study

Liver necropsy from patients infected with human immunodeficiency virus was analyzed in 117 cases. Wide ranges of opportunistic infections were recorded in 47%. Cryptococcosis (21.4%) was the most outstanding infection, followed by tuberculosis (16.2%), cytomegalovirus (5.1%) and penicillosis (3.4%)...

Full description

Saved in:
Bibliographic Details
Main Authors: Parnpen Viriyavejakul, Porntip Rojanasunan, Akravudh Viriyavejakul, Phaiboon Punyarit, Benjanee Punpoowong, Vasant Khachansaksumet, Mario Riganti, Emsri Pongponratn
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26103
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.26103
record_format dspace
spelling th-mahidol.261032018-09-07T16:16:00Z Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study Parnpen Viriyavejakul Porntip Rojanasunan Akravudh Viriyavejakul Phaiboon Punyarit Benjanee Punpoowong Vasant Khachansaksumet Mario Riganti Emsri Pongponratn Mahidol University Thailand Ministry of Public Health Phramongkutklao College of Medicine Medicine Liver necropsy from patients infected with human immunodeficiency virus was analyzed in 117 cases. Wide ranges of opportunistic infections were recorded in 47%. Cryptococcosis (21.4%) was the most outstanding infection, followed by tuberculosis (16.2%), cytomegalovirus (5.1%) and penicillosis (3.4%). Non-specific alterations of the liver tissues included fatty steatosis (49.6%), fibrosis (55.6%), portal inflammation and reactive hepatitis. Cases of chronic active and chronic passive hepatitis and one case of hepatocellular carcinoma were reported. In the infected liver, predominant pathological changes included granuloma and spotty necrosis, which were attributed to tuberculous hepatitis. Infection with Cryptococcus usually showed no associated pathological change. The sensitivity for the clinical diagnosis of Cryptococcus was 88.8% and specificity was 91.7%. For tuberculosis, sensitivity was 20% and specificity was 67.9%. 2018-09-07T09:16:00Z 2018-09-07T09:16:00Z 2000-12-01 Article Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.4 (2000), 663-667 01251562 2-s2.0-0034574687 https://repository.li.mahidol.ac.th/handle/123456789/26103 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034574687&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Parnpen Viriyavejakul
Porntip Rojanasunan
Akravudh Viriyavejakul
Phaiboon Punyarit
Benjanee Punpoowong
Vasant Khachansaksumet
Mario Riganti
Emsri Pongponratn
Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
description Liver necropsy from patients infected with human immunodeficiency virus was analyzed in 117 cases. Wide ranges of opportunistic infections were recorded in 47%. Cryptococcosis (21.4%) was the most outstanding infection, followed by tuberculosis (16.2%), cytomegalovirus (5.1%) and penicillosis (3.4%). Non-specific alterations of the liver tissues included fatty steatosis (49.6%), fibrosis (55.6%), portal inflammation and reactive hepatitis. Cases of chronic active and chronic passive hepatitis and one case of hepatocellular carcinoma were reported. In the infected liver, predominant pathological changes included granuloma and spotty necrosis, which were attributed to tuberculous hepatitis. Infection with Cryptococcus usually showed no associated pathological change. The sensitivity for the clinical diagnosis of Cryptococcus was 88.8% and specificity was 91.7%. For tuberculosis, sensitivity was 20% and specificity was 67.9%.
author2 Mahidol University
author_facet Mahidol University
Parnpen Viriyavejakul
Porntip Rojanasunan
Akravudh Viriyavejakul
Phaiboon Punyarit
Benjanee Punpoowong
Vasant Khachansaksumet
Mario Riganti
Emsri Pongponratn
format Article
author Parnpen Viriyavejakul
Porntip Rojanasunan
Akravudh Viriyavejakul
Phaiboon Punyarit
Benjanee Punpoowong
Vasant Khachansaksumet
Mario Riganti
Emsri Pongponratn
author_sort Parnpen Viriyavejakul
title Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
title_short Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
title_full Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
title_fullStr Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
title_full_unstemmed Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
title_sort opportunistic infections in the liver of hiv-infected patients in thailand: a necropsy study
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26103
_version_ 1763497533532798976