Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand
A new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means of sequence analysis of 9 Thai M. leprae strains, various...
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th-mahidol.261902018-09-07T16:18:49Z Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand Pongrama Ramasoota Waranya Wongwit Prasert Sampunachot Komes Unnarat Maeya Ngamying Stefan B. Svenson Mahidol University Prapradaeng Hospital Leprosy Division Swedish University of Agricultural Sciences Faculty of Veterinary Medicine and Animal Science Sveriges lantbruksuniversitet Medicine A new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means of sequence analysis of 9 Thai M. leprae strains, various mutations in 289 bps of the rpoB gene revealed forms of mutation never before described, such as multiple mutations (ie, mutation at two, three, six, seven, eight and nine positions in the rpoB gene), most of which were point-mutation substitutions (a few of which were silent), and some insertions. This investigation demonstrates that mutation in the rpoB gene of M. leprae strains from Thailand involves more variety than previously reported for rpoB mutation patterns in rifampicin resistance M. leprae strains. 2018-09-07T09:18:49Z 2018-09-07T09:18:49Z 2000-09-01 Article Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.3 (2000), 493-497 01251562 2-s2.0-0034280747 https://repository.li.mahidol.ac.th/handle/123456789/26190 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034280747&origin=inward |
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Medicine Pongrama Ramasoota Waranya Wongwit Prasert Sampunachot Komes Unnarat Maeya Ngamying Stefan B. Svenson Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
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A new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means of sequence analysis of 9 Thai M. leprae strains, various mutations in 289 bps of the rpoB gene revealed forms of mutation never before described, such as multiple mutations (ie, mutation at two, three, six, seven, eight and nine positions in the rpoB gene), most of which were point-mutation substitutions (a few of which were silent), and some insertions. This investigation demonstrates that mutation in the rpoB gene of M. leprae strains from Thailand involves more variety than previously reported for rpoB mutation patterns in rifampicin resistance M. leprae strains. |
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Mahidol University |
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Mahidol University Pongrama Ramasoota Waranya Wongwit Prasert Sampunachot Komes Unnarat Maeya Ngamying Stefan B. Svenson |
format |
Article |
author |
Pongrama Ramasoota Waranya Wongwit Prasert Sampunachot Komes Unnarat Maeya Ngamying Stefan B. Svenson |
author_sort |
Pongrama Ramasoota |
title |
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
title_short |
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
title_full |
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
title_fullStr |
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
title_full_unstemmed |
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand |
title_sort |
multiple mutations in the rpob gene of mycobacterium leprae strains from leprosy patients in thailand |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/26190 |
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1763489129853616128 |