Toxoplasma gondii Antibody in HIV-Infected Persons

Toxoplasmosis in an immunocompromised host was not documented in Thailand until 1992 when HIV/AIDS infection became pandemic. Patients with toxoplasmic encephalitis and cerebral abscess were recorded, particularly from the northern part of the country. However, data on the prevalence of the disease...

Full description

Saved in:
Bibliographic Details
Main Authors: Yaowalark Sukthana, Thaiyooth Chintana, Amorn Lekkla
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26223
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.26223
record_format dspace
spelling th-mahidol.262232018-09-07T16:19:55Z Toxoplasma gondii Antibody in HIV-Infected Persons Yaowalark Sukthana Thaiyooth Chintana Amorn Lekkla Mahidol University Medicine Toxoplasmosis in an immunocompromised host was not documented in Thailand until 1992 when HIV/AIDS infection became pandemic. Patients with toxoplasmic encephalitis and cerebral abscess were recorded, particularly from the northern part of the country. However, data on the prevalence of the disease in HIV/AIDS patients is not yet available. In this study the authors determine the prevalence of T.gondii antibody in HIV persons. During a two-year period 312 serum samples of which 190 were HIV positive and the remaining samples were negative for HIV were tested. In the HIV positive group, 44 samples (23.2%) were positive for toxoplasma IgG antibody, whilst in the HIV negative group 36 samples (29.5%) were positive. All antibody titres found were not higher than 1:64. There is no significant difference of toxoplasma IgG antibody in HIV positive and HIV negative persons (p=0.25). Among the HIV positive and T.gondii antibody positive group, 19 out of 44 persons (43.2%) had symptoms and signs of acute toxoplasmosis involving the eye and/ or the central nervous system. Due to the high reactivation rate, the authors propose that all HIV-infected persons should be tested for T.gondii antibody and prophylactic treatment of opportunistic infection from T.gondii should be considered in those with positive results. 2018-09-07T09:19:55Z 2018-09-07T09:19:55Z 2000-06-01 Article Journal of the Medical Association of Thailand. Vol.83, No.6 (2000), 681-684 01252208 2-s2.0-0034199164 https://repository.li.mahidol.ac.th/handle/123456789/26223 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034199164&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Yaowalark Sukthana
Thaiyooth Chintana
Amorn Lekkla
Toxoplasma gondii Antibody in HIV-Infected Persons
description Toxoplasmosis in an immunocompromised host was not documented in Thailand until 1992 when HIV/AIDS infection became pandemic. Patients with toxoplasmic encephalitis and cerebral abscess were recorded, particularly from the northern part of the country. However, data on the prevalence of the disease in HIV/AIDS patients is not yet available. In this study the authors determine the prevalence of T.gondii antibody in HIV persons. During a two-year period 312 serum samples of which 190 were HIV positive and the remaining samples were negative for HIV were tested. In the HIV positive group, 44 samples (23.2%) were positive for toxoplasma IgG antibody, whilst in the HIV negative group 36 samples (29.5%) were positive. All antibody titres found were not higher than 1:64. There is no significant difference of toxoplasma IgG antibody in HIV positive and HIV negative persons (p=0.25). Among the HIV positive and T.gondii antibody positive group, 19 out of 44 persons (43.2%) had symptoms and signs of acute toxoplasmosis involving the eye and/ or the central nervous system. Due to the high reactivation rate, the authors propose that all HIV-infected persons should be tested for T.gondii antibody and prophylactic treatment of opportunistic infection from T.gondii should be considered in those with positive results.
author2 Mahidol University
author_facet Mahidol University
Yaowalark Sukthana
Thaiyooth Chintana
Amorn Lekkla
format Article
author Yaowalark Sukthana
Thaiyooth Chintana
Amorn Lekkla
author_sort Yaowalark Sukthana
title Toxoplasma gondii Antibody in HIV-Infected Persons
title_short Toxoplasma gondii Antibody in HIV-Infected Persons
title_full Toxoplasma gondii Antibody in HIV-Infected Persons
title_fullStr Toxoplasma gondii Antibody in HIV-Infected Persons
title_full_unstemmed Toxoplasma gondii Antibody in HIV-Infected Persons
title_sort toxoplasma gondii antibody in hiv-infected persons
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26223
_version_ 1763487566014709760