A double-blind placebo-controlled study of an infusion of lexipafant (platelet-activating factor receptor antagonist) in patients with severe sepsis

• Main Authors: Yupin Suputtamongkol, Sunanta Intaranongpai, Michael D. Smith, Brian Angus, Wipada Chaowagul, Chairat Permpikul, Julie A. Simpson, Amorn Leelarasamee, Lloyd Curtis, Nicholas J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/26277

Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe...