Down-regulation of opoid receptor gene expressions in T-lymphocytes of heroin users

• Main Authors: P. Govitrapong, T. Toskulkao, T. Suttitum, V. Akkarapatumwong, N. Kotchabhakdi, S. Vatanatunyakum
• Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/26289
• Institution: Mahidol University

Our previous study indicated a suppression of mitogen-stimulated T-lymphocyte proliferation, both as an in vitro effect of morphine and in heroin addicts. This immunosuppression is possibly mediated via a direct interaction of opioid with opioid receptors on T-cells. Opioid receptor gene expressions...