Dengue infection presenting with central nervous system manifestation
The objective of this study was to investigate the possibility of dengue virus infection causing an abnormal neurologic presentation. Between 1996 and 1998, all pediatric patients with clinical manifestations of encephalitis-like illness who were admitted to the Department of Pediatrics, Siriraj Hos...
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th-mahidol.263012018-09-07T16:22:55Z Dengue infection presenting with central nervous system manifestation Pongkiat Kankirawatana Kulkanya Chokephaibulkit Pilaipan Puthavathana Sutee Yoksan Somchai Apintanapong Viroj Pongthapisit Faculty of Medicine, Siriraj Hospital, Mahidol University Mahidol University Medicine The objective of this study was to investigate the possibility of dengue virus infection causing an abnormal neurologic presentation. Between 1996 and 1998, all pediatric patients with clinical manifestations of encephalitis-like illness who were admitted to the Department of Pediatrics, Siriraj Hospital were prospectively studied for any evidence of dengue virus infection. The diagnosis of dengue virus infection was based on mosquito viral isolation and serologic and polymerase chain reaction (PCR) evidence. Of 44 patients with the preliminary diagnosis of acute viral encephalitis, 8 were diagnosed with dengue infection. All of these 8 patients were diagnosed by serology. In addition to the serologic diagnosis, four also had positive PCR, one had positive viral isolation, and one had both positive PCR and viral isolation. Only two patients were diagnosed by serologic evidence alone. All except one had clinical courses and laboratory findings compatible with typical dengue infection. All had obvious encephalitic clinical manifestations with normal cerebrospinal fluid findings except one patient, who had mildly increased cerebrospinal fluid protein. All of these patients recovered completely and had benign clinical courses except one patient, who developed leakage symptoms. None had liver failure. Dengue virus can cause acute encephalopathy with fever. It can masquerade as other types of acute viral encephalitis. However, its clinical course and prognosis are usually favorable. 2018-09-07T09:22:55Z 2018-09-07T09:22:55Z 2000-01-01 Article Journal of Child Neurology. Vol.15, No.8 (2000), 544-547 10.1177/088307380001500809 08830738 2-s2.0-0033844066 https://repository.li.mahidol.ac.th/handle/123456789/26301 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033844066&origin=inward |
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Medicine Pongkiat Kankirawatana Kulkanya Chokephaibulkit Pilaipan Puthavathana Sutee Yoksan Somchai Apintanapong Viroj Pongthapisit Dengue infection presenting with central nervous system manifestation |
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The objective of this study was to investigate the possibility of dengue virus infection causing an abnormal neurologic presentation. Between 1996 and 1998, all pediatric patients with clinical manifestations of encephalitis-like illness who were admitted to the Department of Pediatrics, Siriraj Hospital were prospectively studied for any evidence of dengue virus infection. The diagnosis of dengue virus infection was based on mosquito viral isolation and serologic and polymerase chain reaction (PCR) evidence. Of 44 patients with the preliminary diagnosis of acute viral encephalitis, 8 were diagnosed with dengue infection. All of these 8 patients were diagnosed by serology. In addition to the serologic diagnosis, four also had positive PCR, one had positive viral isolation, and one had both positive PCR and viral isolation. Only two patients were diagnosed by serologic evidence alone. All except one had clinical courses and laboratory findings compatible with typical dengue infection. All had obvious encephalitic clinical manifestations with normal cerebrospinal fluid findings except one patient, who had mildly increased cerebrospinal fluid protein. All of these patients recovered completely and had benign clinical courses except one patient, who developed leakage symptoms. None had liver failure. Dengue virus can cause acute encephalopathy with fever. It can masquerade as other types of acute viral encephalitis. However, its clinical course and prognosis are usually favorable. |
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Faculty of Medicine, Siriraj Hospital, Mahidol University |
author_facet |
Faculty of Medicine, Siriraj Hospital, Mahidol University Pongkiat Kankirawatana Kulkanya Chokephaibulkit Pilaipan Puthavathana Sutee Yoksan Somchai Apintanapong Viroj Pongthapisit |
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Article |
author |
Pongkiat Kankirawatana Kulkanya Chokephaibulkit Pilaipan Puthavathana Sutee Yoksan Somchai Apintanapong Viroj Pongthapisit |
author_sort |
Pongkiat Kankirawatana |
title |
Dengue infection presenting with central nervous system manifestation |
title_short |
Dengue infection presenting with central nervous system manifestation |
title_full |
Dengue infection presenting with central nervous system manifestation |
title_fullStr |
Dengue infection presenting with central nervous system manifestation |
title_full_unstemmed |
Dengue infection presenting with central nervous system manifestation |
title_sort |
dengue infection presenting with central nervous system manifestation |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/26301 |
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1763491006071701504 |