Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.

Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.

Seventy-one isolates of Cryptococcus neoformans and 5 isolates of Prototheca spp. were tested for in vitro susceptibility against amphotericin B alone and against the combination of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin by broth dilution method...

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Main Authors: Somboon Srimuang, Angkana Chaiprasert, Deja Tanphaichitra, Chularut Prariyachatigul, Watcharin Rungsipanuratn
Other Authors: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26344
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Institution: Mahidol University
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spelling th-mahidol.263442018-09-07T16:24:24Z Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp. Somboon Srimuang Angkana Chaiprasert Deja Tanphaichitra Chularut Prariyachatigul Watcharin Rungsipanuratn Faculty of Medicine, Ramathibodi Hospital, Mahidol University Khon Kaen University Mahidol University Prince of Songkla University Medicine Seventy-one isolates of Cryptococcus neoformans and 5 isolates of Prototheca spp. were tested for in vitro susceptibility against amphotericin B alone and against the combination of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin by broth dilution methods. The combinations of amphotericin B and rifampin produced greater effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did either drug used individually. Flucytosine combined with amphotericin B produced little or no reduction of the MIC compared with amphotericin B alone. 2018-09-07T09:24:24Z 2018-09-07T09:24:24Z 2000-01-01 Article Journal of the Medical Association of Thailand. Vol.83, No.1 (2000), 57-60 01252208 2-s2.0-0034099761 https://repository.li.mahidol.ac.th/handle/123456789/26344 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034099761&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Somboon Srimuang
Angkana Chaiprasert
Deja Tanphaichitra
Chularut Prariyachatigul
Watcharin Rungsipanuratn
Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
description Seventy-one isolates of Cryptococcus neoformans and 5 isolates of Prototheca spp. were tested for in vitro susceptibility against amphotericin B alone and against the combination of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin by broth dilution methods. The combinations of amphotericin B and rifampin produced greater effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did either drug used individually. Flucytosine combined with amphotericin B produced little or no reduction of the MIC compared with amphotericin B alone.
author2 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
author_facet Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Somboon Srimuang
Angkana Chaiprasert
Deja Tanphaichitra
Chularut Prariyachatigul
Watcharin Rungsipanuratn
format Article
author Somboon Srimuang
Angkana Chaiprasert
Deja Tanphaichitra
Chularut Prariyachatigul
Watcharin Rungsipanuratn
author_sort Somboon Srimuang
title Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
title_short Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
title_full Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
title_fullStr Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
title_full_unstemmed Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp.
title_sort antifungal drug combinations for cryptococcus neoformans and prototheca spp.
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26344
_version_ 1763490234488586240

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