Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome

The effects of age, parity and male infertility status on pregnancy outcome were studied in a cohort of 720 women receiving donor insemination (DI) treatment. Twenty-two percent of women failed to complete the treatment, leaving 562 women receiving 3202 cycles of DI for assessment. Of the 321 of pre...

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Main Authors: Gulam Bahadur, Jacob Farhi, K. L.Eddie Ling, Kitirat Techatraisak, Ashfaq Ashraf, Abdul Wakil Oyede, Shantilal Priya, Raheala Wafa
Other Authors: UCL Medical School
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26348
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spelling th-mahidol.263482018-09-07T16:24:34Z Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome Gulam Bahadur Jacob Farhi K. L.Eddie Ling Kitirat Techatraisak Ashfaq Ashraf Abdul Wakil Oyede Shantilal Priya Raheala Wafa UCL Medical School Wolfson Medical Centre Mahidol University Medicine The effects of age, parity and male infertility status on pregnancy outcome were studied in a cohort of 720 women receiving donor insemination (DI) treatment. Twenty-two percent of women failed to complete the treatment, leaving 562 women receiving 3202 cycles of DI for assessment. Of the 321 of pregnancies achieved, 57 (17.8%) ended in a miscarriage. After further DI treatments, 64.7% of mothers who had miscarried succeeded in giving birth. There was some evidence to indicate a trend of decreasing pregnancy rate with increasing maternal age, although this result was not significant (log rank trend statistics = 3.44, P > 0.05). The pregnancy rates of multiparous and primiparous women were significantly different, irrespective of their partner's infertility status (azoospermia: log rank statistics = 3.74, P ≤ 0.05; oligozoospermia: log rank statistics = 4.71, P < 0.03). Furthermore, multiparous women were more likely to become pregnant than primiparous women (azoospermia: hazard ratio = 1.29; oligozoospermia: hazard ratio = 1.50). There was no significant association between miscarriage rate and maternal age (log rank trend statistics = 0.99, P > 0.05). The small number of older women (> 35 years) may confound this result. The mean (± SD) sperm donor age was 23.6 years (± 3.5 years). The implications of these observations are discussed. 2018-09-07T09:24:34Z 2018-09-07T09:24:34Z 2000-01-01 Article Human Fertility. Vol.3, No.3 (2000), 207-213 10.1080/1464727002000199001 14647273 2-s2.0-0033866109 https://repository.li.mahidol.ac.th/handle/123456789/26348 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033866109&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Gulam Bahadur
Jacob Farhi
K. L.Eddie Ling
Kitirat Techatraisak
Ashfaq Ashraf
Abdul Wakil Oyede
Shantilal Priya
Raheala Wafa
Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
description The effects of age, parity and male infertility status on pregnancy outcome were studied in a cohort of 720 women receiving donor insemination (DI) treatment. Twenty-two percent of women failed to complete the treatment, leaving 562 women receiving 3202 cycles of DI for assessment. Of the 321 of pregnancies achieved, 57 (17.8%) ended in a miscarriage. After further DI treatments, 64.7% of mothers who had miscarried succeeded in giving birth. There was some evidence to indicate a trend of decreasing pregnancy rate with increasing maternal age, although this result was not significant (log rank trend statistics = 3.44, P > 0.05). The pregnancy rates of multiparous and primiparous women were significantly different, irrespective of their partner's infertility status (azoospermia: log rank statistics = 3.74, P ≤ 0.05; oligozoospermia: log rank statistics = 4.71, P < 0.03). Furthermore, multiparous women were more likely to become pregnant than primiparous women (azoospermia: hazard ratio = 1.29; oligozoospermia: hazard ratio = 1.50). There was no significant association between miscarriage rate and maternal age (log rank trend statistics = 0.99, P > 0.05). The small number of older women (> 35 years) may confound this result. The mean (± SD) sperm donor age was 23.6 years (± 3.5 years). The implications of these observations are discussed.
author2 UCL Medical School
author_facet UCL Medical School
Gulam Bahadur
Jacob Farhi
K. L.Eddie Ling
Kitirat Techatraisak
Ashfaq Ashraf
Abdul Wakil Oyede
Shantilal Priya
Raheala Wafa
format Article
author Gulam Bahadur
Jacob Farhi
K. L.Eddie Ling
Kitirat Techatraisak
Ashfaq Ashraf
Abdul Wakil Oyede
Shantilal Priya
Raheala Wafa
author_sort Gulam Bahadur
title Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
title_short Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
title_full Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
title_fullStr Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
title_full_unstemmed Pregnancy and miscarriage rates in 3978 donor insemination cycles: Effect of age, parity and partner's infertility status on pregnancy outcome
title_sort pregnancy and miscarriage rates in 3978 donor insemination cycles: effect of age, parity and partner's infertility status on pregnancy outcome
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26348
_version_ 1763497364719403008