Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H<inf>2</inf>synthases by ibuprofen, naproxen, and indomethacin

• Main Authors: Maisa S. Jaradat, Buanus Wongsud, Srichan Phornchirasilp, Shamina M. Rangwala, Gamal Shams, Melissa Sutton, Karl J. Romstedt, Daniel J. Noonan, Dennis R. Feller
• Other Authors: University of Mississippi
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/26425
• Institution: Mahidol University

A series of nonsteroidal anti-inflammatory drugs (NSAIDs) [S(+)-naproxen, ibuprofen isomers, and indomethacin] were evaluated for their activation of peroxisome proliferator-activated receptor (PPAR) α and γ isoforms in CV-1 cells co-transfected with rat PPAR α and γ, and peroxisome proliferator res...