Structural basis for selectivity and toxicity of ribosomal antibiotics

Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance m...

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Bibliographic Details
Main Authors: Erik C. Böttger, Burkhard Springer, Therdsak Prammananan, Yishak Kidan, Peter Sander
Other Authors: Medizinische Hochschule Hannover (MHH)
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26464
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Institution: Mahidol University