Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

• Main Authors: Sadudee Chotirat, Wanna Thongnoppakhun, Orathai Promsuwicha, Chetsada Boonthimat, Chirayu U Auewarakul
• Other Authors: Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Medicine
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Acute myeloid leukemia; Isocitrate dehydrogenase; Metabolic enzymes; IDH1; IDH2; Cooperative mutations; Normal karyotype
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2655
• Institution: Mahidol University

Background: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to a-ketoglutarate. Acquired somatic mutations of IDH1 and IDH2 have recently been reported in some types of brain tumors and a small p...