Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais

Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais

The HIV-1 prime boost phase I/II vaccine trial using a recombinant canarypox vector, vCP1521, containing subtype E env (gp120), and subtype B env (gp41), gag and protease has started in Thailand. We have demonstrated that although 4 from 15 human immunodeficiency virus type 1 (HIV-1) seronegative in...

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Main Authors: W. Kantakamalakul, J. Cox, U. Kositanont, S. Siritantikorn, K. Limbach, D. Birx, P. Thongcharoen, P. Puthavathana
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Immunology and Microbiology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26559
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spelling th-mahidol.265592018-09-07T16:46:56Z Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais W. Kantakamalakul J. Cox U. Kositanont S. Siritantikorn K. Limbach D. Birx P. Thongcharoen P. Puthavathana Mahidol University Immunology and Microbiology Medicine The HIV-1 prime boost phase I/II vaccine trial using a recombinant canarypox vector, vCP1521, containing subtype E env (gp120), and subtype B env (gp41), gag and protease has started in Thailand. We have demonstrated that although 4 from 15 human immunodeficiency virus type 1 (HIV-1) seronegative individuals showed cytotoxic T lymphocyte (CTL) responses to vaccinia virus antigens, none of them showed specific CTL responses to subtype E Env after in vitro stimulation. This preliminary study suggests that specific CTL responses to subtype E envelope detected in HIV-1 seronegative individuals after vaccination should be considered as specific responses to the immunization. 2018-09-07T09:41:23Z 2018-09-07T09:41:23Z 2001-08-14 Article Asian Pacific Journal of Allergy and Immunology. Vol.19, No.1 (2001), 17-22 0125877X 2-s2.0-0034920984 https://repository.li.mahidol.ac.th/handle/123456789/26559 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034920984&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
W. Kantakamalakul
J. Cox
U. Kositanont
S. Siritantikorn
K. Limbach
D. Birx
P. Thongcharoen
P. Puthavathana
Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
description The HIV-1 prime boost phase I/II vaccine trial using a recombinant canarypox vector, vCP1521, containing subtype E env (gp120), and subtype B env (gp41), gag and protease has started in Thailand. We have demonstrated that although 4 from 15 human immunodeficiency virus type 1 (HIV-1) seronegative individuals showed cytotoxic T lymphocyte (CTL) responses to vaccinia virus antigens, none of them showed specific CTL responses to subtype E Env after in vitro stimulation. This preliminary study suggests that specific CTL responses to subtype E envelope detected in HIV-1 seronegative individuals after vaccination should be considered as specific responses to the immunization.
author2 Mahidol University
author_facet Mahidol University
W. Kantakamalakul
J. Cox
U. Kositanont
S. Siritantikorn
K. Limbach
D. Birx
P. Thongcharoen
P. Puthavathana
format Article
author W. Kantakamalakul
J. Cox
U. Kositanont
S. Siritantikorn
K. Limbach
D. Birx
P. Thongcharoen
P. Puthavathana
author_sort W. Kantakamalakul
title Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
title_short Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
title_full Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
title_fullStr Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
title_full_unstemmed Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
title_sort cytotoxic t lymphocyte responses to vaccinia virus antigens but not hiv-1 subtype e envelope protein seen in hiv-1 seronegative thais
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26559
_version_ 1763494082469953536

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