Identification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition

• Main Authors: Vip Viprakasit, Tyan, Paul, Sarayuth Rodmai, Taher, Ali T.
• Other Authors: Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pediatrics and Thalassemia Center
• Format: Review Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Non-transfusion-dependent thalassaemia; Thalassaemia intermedia; HbE disease; HbH disease; Iron chelation; RBC transfusion; Hydroxyurea
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2658
• Institution: Mahidol University

Patients with non-transfusion-dependent thalassaemia (NTDT) have a genetic defect or combination of defects that affect haemoglobin synthesis, but which is not severe enough to require regular blood transfusions. The carrier frequency of NTDT is high (up to 80% in some parts of the world) but the...