Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism

• Main Authors: Kittipong Maneechotesuwan, Kanda Kasetsinsombat, Adisak Wongkajornsilp, Barnes, Peter J.
• Other Authors: Mahidol University. Faculty of Medicine Siriraj Hospital. Division of Respiratory Diseases and Tuberculosis
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Simvastatin; Adenosine deaminase; Osteopontin; IL-13; COPD
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2682
• Institution: Mahidol University

Background: Adenosine deaminase (ADA) and osteopontin (OPN) may play opposing roles in the pathogenesis of COPD. Deficiency of ADA results in enhanced adenosine signaling which up-regulates OPN expression. Although statins suppress OPN in cancer cells, little is known about their effects on ADA an...