Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer
Background: Occasionally, breast cancer relapses more than 5 years after initial treatment, sometimes with highly aggressive disease in such late-recurring patients. This study investigated predictors of recurrence after more than 5 years in operable breast cancer. Methods: We retrospectively ana...
Saved in:
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/2684 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
Language: | English |
id |
th-mahidol.2684 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.26842023-04-12T15:20:55Z Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer Pattaraporn Wangchinda Suthinee Ithimakin Mahidol University. Department of Internal Medicine Siriraj Hospital. Division of Medical Oncology Open Access article Breast cancer Clinicopathological Late recurrence Luminal breast cancer Background: Occasionally, breast cancer relapses more than 5 years after initial treatment, sometimes with highly aggressive disease in such late-recurring patients. This study investigated predictors of recurrence after more than 5 years in operable breast cancer. Methods: We retrospectively analyzed data from patients with recurrent breast cancer treated at Siriraj Hospital. Patients were divided into those whose relapse times were longer or shorter than 5 years. Factors that predicted late recurrence were analyzed in both the overall population and the luminal subgroup. Patterns of relapse, changes in biomarkers, and time to disease progression after first relapse were also recorded. Results: We included 300 women whose breast cancers recurred between 2005 and 2013, of whom 180 had recurrence within 5 years of diagnosis and 120 later than 5 years (median time to recurrence: 45.43 months; range: 4.4–250.3 months). Tumors larger than 2 cm, lymph node metastasis, and high nuclear grade were related with early recurrence. Estrogen receptor-positive, progesterone receptor-positive, and HER2− disease predicted late recurrence. Almost all late-relapsing patients with luminal tumors had high estrogen receptor (ER+) titers (≥50 %) and HER2− disease. Liver and brain were the most common early recurrence sites. Biomarkers did not significantly change by time of recurrence. Conclusions: ER+/PR+ and HER2− patients have higher risk of recurrence later than 5 years, especially in patients with high ER titer and low nuclear grade. Larger and node-positive tumors had higher risk of early recurrence. 2017-08-07T04:11:06Z 2017-08-07T04:11:06Z 2017-08-07 2016 Research Article World Journal of Surgical Oncology. Vol. 14, (2016), 223 10.1186/s12957-016-0988-0 https://repository.li.mahidol.ac.th/handle/123456789/2684 eng Mahidol University BioMed Central application/pdf |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
language |
English |
topic |
Open Access article Breast cancer Clinicopathological Late recurrence Luminal breast cancer |
spellingShingle |
Open Access article Breast cancer Clinicopathological Late recurrence Luminal breast cancer Pattaraporn Wangchinda Suthinee Ithimakin Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
description |
Background: Occasionally, breast cancer relapses more than 5 years after initial treatment, sometimes with highly
aggressive disease in such late-recurring patients. This study investigated predictors of recurrence after more than
5 years in operable breast cancer.
Methods: We retrospectively analyzed data from patients with recurrent breast cancer treated at Siriraj Hospital.
Patients were divided into those whose relapse times were longer or shorter than 5 years. Factors that predicted
late recurrence were analyzed in both the overall population and the luminal subgroup. Patterns of relapse,
changes in biomarkers, and time to disease progression after first relapse were also recorded.
Results: We included 300 women whose breast cancers recurred between 2005 and 2013, of whom 180 had
recurrence within 5 years of diagnosis and 120 later than 5 years (median time to recurrence: 45.43 months; range:
4.4–250.3 months). Tumors larger than 2 cm, lymph node metastasis, and high nuclear grade were related with
early recurrence. Estrogen receptor-positive, progesterone receptor-positive, and HER2− disease predicted late
recurrence. Almost all late-relapsing patients with luminal tumors had high estrogen receptor (ER+) titers (≥50 %)
and HER2− disease. Liver and brain were the most common early recurrence sites. Biomarkers did not significantly
change by time of recurrence.
Conclusions: ER+/PR+ and HER2− patients have higher risk of recurrence later than 5 years, especially in patients
with high ER titer and low nuclear grade. Larger and node-positive tumors had higher risk of early recurrence. |
author2 |
Mahidol University. Department of Internal Medicine Siriraj Hospital. Division of Medical Oncology |
author_facet |
Mahidol University. Department of Internal Medicine Siriraj Hospital. Division of Medical Oncology Pattaraporn Wangchinda Suthinee Ithimakin |
format |
Article |
author |
Pattaraporn Wangchinda Suthinee Ithimakin |
author_sort |
Pattaraporn Wangchinda |
title |
Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
title_short |
Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
title_full |
Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
title_fullStr |
Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
title_full_unstemmed |
Factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
title_sort |
factors that predict recurrence later than 5 years after initial treatment in operable breast cancer |
publishDate |
2017 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/2684 |
_version_ |
1781414903621353472 |