Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999

A retrospective study on nosocomial bloodstream infection (NBSI) in pediatric patients hospitalized at Siriraj Hospital from January 1996 to December 1999 was performed. Of the 18,087 blood specimens sent for culture, 533 (3%) were positive for organisms after 72 hours of hospitalization and were de...

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Main Authors: Kanokporn Mongkolrattanothai, Kulkanya Chokephaibulkit, Tharathip Kolatat, Nirun Vanprapar, Sanay Chearskul, Nitaya Srihapol, Varaporn Pumsawan, Sumalee Pakaworawuth, Chertsak Dhiraputra
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26855
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spelling th-mahidol.268552018-09-07T16:50:58Z Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999 Kanokporn Mongkolrattanothai Kulkanya Chokephaibulkit Tharathip Kolatat Nirun Vanprapar Sanay Chearskul Nitaya Srihapol Varaporn Pumsawan Sumalee Pakaworawuth Chertsak Dhiraputra Mahidol University Medicine A retrospective study on nosocomial bloodstream infection (NBSI) in pediatric patients hospitalized at Siriraj Hospital from January 1996 to December 1999 was performed. Of the 18,087 blood specimens sent for culture, 533 (3%) were positive for organisms after 72 hours of hospitalization and were defined as NBSI. The rate of NBSI detected in blood culture specimens was highest among neonates (5.2%). Gram-positive cocci and gram-negative rods caused NBSI in an equal proportion (46% and 44% respectively) and Candida caused 10 per cent of NBSI. Coagulase-negative staphylococci was the most common pathogen followed by K. pneumoniae and Enterobacter. Antibiogram showed that 15 of the 35 (43%) S. aureus identified were methicillin-resistant. Only 35-38 per cent of Enterobacteriaceae were sensitive to cefotaxime or ceftazidime. Cefoxitin was still effective against 95 per cent of K. pneumoniae. Compared with other third generation cephalosporins, combination of cefoperazone and betalactamase-inhibitor (sulbactam) possessed an increased in vitro efficacy against K. pneumoniae, Enterobacter, E. coli, Acinetobacter and non-fermentative gram-negative rods. Resistant rate of amikacin among all gram negative rods was 25-69 per cent. Ciprofloxacin sensitivity varied from 62-100 per cent among all gram-negative rods. Imipenem was excellent against all gram-negative rods with the sensitivity of 80-100 per cent. Epidemiological data of this study is important for the decision of the appropriate empirical antimicrobial treatment in our hospital. 2018-09-07T09:50:57Z 2018-09-07T09:50:57Z 2001-02-01 Article Journal of the Medical Association of Thailand. Vol.84, No.2 (2001), 160-165 01252208 2-s2.0-14344274944 https://repository.li.mahidol.ac.th/handle/123456789/26855 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=14344274944&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Kanokporn Mongkolrattanothai
Kulkanya Chokephaibulkit
Tharathip Kolatat
Nirun Vanprapar
Sanay Chearskul
Nitaya Srihapol
Varaporn Pumsawan
Sumalee Pakaworawuth
Chertsak Dhiraputra
Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
description A retrospective study on nosocomial bloodstream infection (NBSI) in pediatric patients hospitalized at Siriraj Hospital from January 1996 to December 1999 was performed. Of the 18,087 blood specimens sent for culture, 533 (3%) were positive for organisms after 72 hours of hospitalization and were defined as NBSI. The rate of NBSI detected in blood culture specimens was highest among neonates (5.2%). Gram-positive cocci and gram-negative rods caused NBSI in an equal proportion (46% and 44% respectively) and Candida caused 10 per cent of NBSI. Coagulase-negative staphylococci was the most common pathogen followed by K. pneumoniae and Enterobacter. Antibiogram showed that 15 of the 35 (43%) S. aureus identified were methicillin-resistant. Only 35-38 per cent of Enterobacteriaceae were sensitive to cefotaxime or ceftazidime. Cefoxitin was still effective against 95 per cent of K. pneumoniae. Compared with other third generation cephalosporins, combination of cefoperazone and betalactamase-inhibitor (sulbactam) possessed an increased in vitro efficacy against K. pneumoniae, Enterobacter, E. coli, Acinetobacter and non-fermentative gram-negative rods. Resistant rate of amikacin among all gram negative rods was 25-69 per cent. Ciprofloxacin sensitivity varied from 62-100 per cent among all gram-negative rods. Imipenem was excellent against all gram-negative rods with the sensitivity of 80-100 per cent. Epidemiological data of this study is important for the decision of the appropriate empirical antimicrobial treatment in our hospital.
author2 Mahidol University
author_facet Mahidol University
Kanokporn Mongkolrattanothai
Kulkanya Chokephaibulkit
Tharathip Kolatat
Nirun Vanprapar
Sanay Chearskul
Nitaya Srihapol
Varaporn Pumsawan
Sumalee Pakaworawuth
Chertsak Dhiraputra
format Article
author Kanokporn Mongkolrattanothai
Kulkanya Chokephaibulkit
Tharathip Kolatat
Nirun Vanprapar
Sanay Chearskul
Nitaya Srihapol
Varaporn Pumsawan
Sumalee Pakaworawuth
Chertsak Dhiraputra
author_sort Kanokporn Mongkolrattanothai
title Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
title_short Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
title_full Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
title_fullStr Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
title_full_unstemmed Nosocomial bloodstream infection in pediatric patients: Siriraj hospital, bangkok; 1996-1999
title_sort nosocomial bloodstream infection in pediatric patients: siriraj hospital, bangkok; 1996-1999
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/26855
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