IFNGR1 polymorphisms in Thai malaria patients

IFNGR1 polymorphisms in Thai malaria patients

Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria. To examine possible association of the IFN-γ receptor 1 (IFNGR1) polymorphisms with cerebral malaria, 312 adult patients with Plasmodium falciparum malaria (203 mild and 109 cerebral malaria patients) l...

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Bibliographic Details
Main Authors: Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Katsushi Tokunaga, Naoyuki Tsuchiya, Jun Ohashi
Other Authors: University of Tsukuba
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/26956
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Institution: Mahidol University
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Summary:Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria. To examine possible association of the IFN-γ receptor 1 (IFNGR1) polymorphisms with cerebral malaria, 312 adult patients with Plasmodium falciparum malaria (203 mild and 109 cerebral malaria patients) living in northwest Thailand were genotyped for six single nucleotide polymorphisms (SNPs) including -56T/C (rs2234711) and a microsatellite marker in IFNGR1. A case-control association analysis failed to detect significant association between the IFNGR1 polymorphisms and cerebral malaria, thus implying that the IFNGR1 polymorphism may not be a major genetic factor influencing the development of cerebral malaria in the Thai population. These data also provide useful information for future genetic studies of IFNG polymorphisms in Thai patients. © 2009 Elsevier B.V. All rights reserved.

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