Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells

• Main Authors: Wilaiwan Wisessmith, Pansiri Phansuwan-Pujito, Piyarat Govitrapong, Banthit Chetsawang
• Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27232
• Institution: Mahidol University

Several studies demonstrated that methamphetamine (MA)-treated human neuroblastoma cells exhibit increased oxidative stress, which regulates intracellular signaling cascades leading to cell death. Melatonin has a potential as a direct free radical scavenger and protects against cell death caused by...