Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/b-thalassemia

• Main Authors: Saranyoo Ponnikorn, Tasanee Panichakul, Kitima Sresanga, Chokdee Wongborisuth, Sittiruk Roytrakul, Suradej Hongeng, Sumalee Tungpradabkul
• Other Authors: Mahidol University. Faculty of Science. Department of Biochemistry
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Phosphoproteome; Hemoglobin E/β-thalassemia; HSCs/CD34+; apoptosis
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2724
• Institution: Mahidol University

Background: Hemoglobin E/b-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of bthalassemia in terms of the acceleration of apoptotic cell death. Ineffective erythropoiesi...