Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes

• Main Authors: Paul J. Norman, Laurent Abi-Rached, Ketevan Gendzekhadze, John A. Hammond, Achim K. Moesta, Deepti Sharma, Thorsten Graef, Karina L. McQueen, Lisbeth A. Guethlein, Christine V.F. Carrington, Dasdayanee Chandanayingyong, Yih Hsin Chang, Catalina Crespí, Güher Saruhan-Direskeneli, Kamran Hameed, Giorgi Kamkamidze, Kwadwo A. Koram, Zulay Layrisse, Nuria Matamoros, Joan Milà, Hee Park Myoung, Ramasamy M. Pitchappan, D. Dan Ramdath, Ming Yuh Shiau, Henry A.F. Stephens, Siske Struik, Dolly Tyan, David H. Verity, Robert W. Vaughan, Ronald W. Davis, Patricia A. Fraser, Eleanor M. Riley, Mostafa Ronaghi, Peter Parham
• Other Authors: Stanford University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27242
• Institution: Mahidol University

Natural killer (NK) cells contribute to the essential functions of innate immunity and reproduction. Various genes encode NK cell receptors that recognize the major histocompatibility complex (MHC) Class I molecules expressed by other cells. For primate NK cells, the killer-cell immunoglobulin-like...