Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers

The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for...

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Bibliographic Details
Main Authors: Norased Nasongkia, Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean M.J. Fréchet, Francis C. Szoka
Other Authors: University of California, San Francisco
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/27263
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Institution: Mahidol University