Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP⁺-treated human neuroblastoma cells with melatonin

• Main Authors: Banthit Chetsawang, Jirapa Chetsawang, Piyarat Govitrapong
• Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27324
• Institution: Mahidol University

Neuroprotective effects of melatonin against oxidative stress-induced neuronal cell degeneration in human SH-SY5Y neuroblastoma cells were investigated in this report. The results demonstrate that exogenous administration of H2O2 and 1-methyl, 4-phenyl, pyridinium ion (MPP+) significantly decreased...