Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

• Main Authors: Supaluk Prachayasittikul, Patumporn Manam, Maneekarn Chinworrungsee, Chartchalerm Isarankura-Na-ayudhya, Somsak Ruchirawat, Virapong Prachayasittikul
• Other Authors: Srinakharinwirot University
• Format: Article
• Published: 2018
• Subjects: Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27392
• Institution: Mahidol University

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmaste...