Involvement of the liver in dengue infections
Dengue virus, the causative agent of dengue fever (DF) and more severe forms of the disease - dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) - can infect a number of different types of cells. While monocytes and macrophages are considered to be primary target cells driving the patho...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Review |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/27609 |
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| Institution: | Mahidol University |
| Summary: | Dengue virus, the causative agent of dengue fever (DF) and more severe forms of the disease - dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) - can infect a number of different types of cells. While monocytes and macrophages are considered to be primary target cells driving the pathology of the disease, numerous studies have implicated the liver as a site of dengue virus replication and both clinical observations and experimental data support a role of the liver in dengue disease. This review aims to provide a brief overview of the data supporting a role of the liver in the pathology of dengue disease. |
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