The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii

• Main Authors: Popchai Ngamskulrungroj, Uwe Himmelreich, Julia A. Breger, Christabel Wilson, Methee Chayakulkeeree, Mark B. Krockenberger, Richard Malik, Heide Marie Daniel, Dena Toffaletti, Julianne T. Djordjevic, Eleftherios Mylonakis, Wieland Meyer, John R. Perfect
• Other Authors: Duke University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27653
• Institution: Mahidol University

The trehalose pathway is essential for stress tolerance and virulence in fungi. We investigated the importance of this pathway for virulence of the pathogenic yeast Cryptococcus gattii using the highly virulent Vancouver Island, Canada, outbreak strain R265. Three genes putatively involved in trehal...