Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center

Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and ou...

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Main Authors: P. Benjasupattananan, T. Simasathein, P. Vichyanond, V. Leungwedchakarn, N. Visitsunthorn, P. Pacharn, O. Jirapongsananuruk
Other Authors: Mahidol University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/27716
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spelling th-mahidol.277162018-09-13T14:01:32Z Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center P. Benjasupattananan T. Simasathein P. Vichyanond V. Leungwedchakarn N. Visitsunthorn P. Pacharn O. Jirapongsananuruk Mahidol University Immunology and Microbiology Medicine Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and outcomes of patients with PID in Thailand. Methods: Medical records of PID patients in the past 18 years were reviewed. Results: Sixty-seven children were registered. Antibody deficiencies were the most common PID (52.2%), followed by combined T cell and B cell immunodeficiencies (25.4%), other well-defined immunodeficiency syndromes (11.9%), and phagocytic defects (10.4%). The most common presentations of antibody deficiencies, combined T cell and B cell immunodeficiencies, and phagocytic defects were infection in the upper respiratory tract (74.3%), gastrointestinal tract (82.4%), and skin (85.7%), respectively. The highest mortality rate (52.9%) was found in severe combined immunodeficiency. Conclusion: These results provide clinical features of PID in Thailand. Knowing these features will lead to prompt diagnosis and appropriate management. © 2009 Springer Science+Business Media, LLC. 2018-09-13T06:43:25Z 2018-09-13T06:43:25Z 2009-05-01 Article Journal of Clinical Immunology. Vol.29, No.3 (2009), 357-364 10.1007/s10875-008-9273-5 15732592 02719142 2-s2.0-67349273016 https://repository.li.mahidol.ac.th/handle/123456789/27716 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67349273016&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
P. Benjasupattananan
T. Simasathein
P. Vichyanond
V. Leungwedchakarn
N. Visitsunthorn
P. Pacharn
O. Jirapongsananuruk
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
description Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and outcomes of patients with PID in Thailand. Methods: Medical records of PID patients in the past 18 years were reviewed. Results: Sixty-seven children were registered. Antibody deficiencies were the most common PID (52.2%), followed by combined T cell and B cell immunodeficiencies (25.4%), other well-defined immunodeficiency syndromes (11.9%), and phagocytic defects (10.4%). The most common presentations of antibody deficiencies, combined T cell and B cell immunodeficiencies, and phagocytic defects were infection in the upper respiratory tract (74.3%), gastrointestinal tract (82.4%), and skin (85.7%), respectively. The highest mortality rate (52.9%) was found in severe combined immunodeficiency. Conclusion: These results provide clinical features of PID in Thailand. Knowing these features will lead to prompt diagnosis and appropriate management. © 2009 Springer Science+Business Media, LLC.
author2 Mahidol University
author_facet Mahidol University
P. Benjasupattananan
T. Simasathein
P. Vichyanond
V. Leungwedchakarn
N. Visitsunthorn
P. Pacharn
O. Jirapongsananuruk
format Article
author P. Benjasupattananan
T. Simasathein
P. Vichyanond
V. Leungwedchakarn
N. Visitsunthorn
P. Pacharn
O. Jirapongsananuruk
author_sort P. Benjasupattananan
title Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
title_short Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
title_full Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
title_fullStr Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
title_full_unstemmed Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
title_sort clinical characteristics and outcomes of primary immunodeficiencies in thai children: an 18-year experience from a tertiary care center
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/27716
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