Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center
Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and ou...
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th-mahidol.277162018-09-13T14:01:32Z Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center P. Benjasupattananan T. Simasathein P. Vichyanond V. Leungwedchakarn N. Visitsunthorn P. Pacharn O. Jirapongsananuruk Mahidol University Immunology and Microbiology Medicine Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and outcomes of patients with PID in Thailand. Methods: Medical records of PID patients in the past 18 years were reviewed. Results: Sixty-seven children were registered. Antibody deficiencies were the most common PID (52.2%), followed by combined T cell and B cell immunodeficiencies (25.4%), other well-defined immunodeficiency syndromes (11.9%), and phagocytic defects (10.4%). The most common presentations of antibody deficiencies, combined T cell and B cell immunodeficiencies, and phagocytic defects were infection in the upper respiratory tract (74.3%), gastrointestinal tract (82.4%), and skin (85.7%), respectively. The highest mortality rate (52.9%) was found in severe combined immunodeficiency. Conclusion: These results provide clinical features of PID in Thailand. Knowing these features will lead to prompt diagnosis and appropriate management. © 2009 Springer Science+Business Media, LLC. 2018-09-13T06:43:25Z 2018-09-13T06:43:25Z 2009-05-01 Article Journal of Clinical Immunology. Vol.29, No.3 (2009), 357-364 10.1007/s10875-008-9273-5 15732592 02719142 2-s2.0-67349273016 https://repository.li.mahidol.ac.th/handle/123456789/27716 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67349273016&origin=inward |
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Immunology and Microbiology Medicine P. Benjasupattananan T. Simasathein P. Vichyanond V. Leungwedchakarn N. Visitsunthorn P. Pacharn O. Jirapongsananuruk Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
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Abstracts: Introduction: Early diagnosis and treatment are keys to improve survival of patients with primary immunodeficiency diseases (PID). The clinical characteristics of these patients in Thailand were not well defined. Objective: This study aimed to determine the clinical characteristics and outcomes of patients with PID in Thailand. Methods: Medical records of PID patients in the past 18 years were reviewed. Results: Sixty-seven children were registered. Antibody deficiencies were the most common PID (52.2%), followed by combined T cell and B cell immunodeficiencies (25.4%), other well-defined immunodeficiency syndromes (11.9%), and phagocytic defects (10.4%). The most common presentations of antibody deficiencies, combined T cell and B cell immunodeficiencies, and phagocytic defects were infection in the upper respiratory tract (74.3%), gastrointestinal tract (82.4%), and skin (85.7%), respectively. The highest mortality rate (52.9%) was found in severe combined immunodeficiency. Conclusion: These results provide clinical features of PID in Thailand. Knowing these features will lead to prompt diagnosis and appropriate management. © 2009 Springer Science+Business Media, LLC. |
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Mahidol University |
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Mahidol University P. Benjasupattananan T. Simasathein P. Vichyanond V. Leungwedchakarn N. Visitsunthorn P. Pacharn O. Jirapongsananuruk |
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Article |
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P. Benjasupattananan T. Simasathein P. Vichyanond V. Leungwedchakarn N. Visitsunthorn P. Pacharn O. Jirapongsananuruk |
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P. Benjasupattananan |
title |
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
title_short |
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
title_full |
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
title_fullStr |
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
title_full_unstemmed |
Clinical characteristics and outcomes of primary immunodeficiencies in thai children: An 18-year experience from a tertiary care center |
title_sort |
clinical characteristics and outcomes of primary immunodeficiencies in thai children: an 18-year experience from a tertiary care center |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/27716 |
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1763491192536825856 |