Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads

• Main Authors: Pavel Bostik, Jaruda Kobkitjaroen, Weining Tang, Francois Villinger, Lara E. Pereira, Dawn M. Little, Susan T. Stephenson, Mark Bouzyk, Aftab A. Ansari
• Other Authors: Emory University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27729
• Institution: Mahidol University

NK cells have been established as an important effector of innate immunity in a variety of viral infections. In HIV-1 infection in humans, alterations of NK cell function, frequency, and expression of various NK receptors have been reported to be associated with differential dynamics of disease prog...