Pharmacokinetics of high-dose oseltamivir in healthy volunteers

• Main Authors: Y. Wattanagoon, K. Stepniewska, N. Lindegårdh, S. Pukrittayakamee, U. Silachamroon, W. Piyaphanee, T. Singtoroj, W. Hanpithakpong, G. Davies, J. Taming, W. Pongtavornpinyo, C. Fukuda, P. Singhasivanon, N. P J Day, N. J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28171

The effects of loading doses and probenecid coadministration on oseltamivir pharmacokinetics at four increasing dose levels in groups of eight healthy adult Thai volunteers (125 individual series) were evaluated. Doses of up to 675 mg were well-tolerated. The pharmacokinetics were dose linear. Oselt...