Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells

• Main Authors: Egarit Noulsri, Des R. Richardson, Surada Lerdwana, Suthat Fucharoen, Tetsuo Yamagishi, Danuta S. Kalinowski, Kovit Pattanapanyasat
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28177

Iron chelators have been reported to induce apoptosis and cell cycle arrest in cancer cells. Recent studies suggest broad and selective antitumor activity of the new iron chelator, di-2-pyridylketone-4, 4-dimethyl-3-thiosemicarbazone (Dp44mT; Whitnall et al., Proc Natl Acad Sci USA 2006;103:14901-14...