Modification of platelet shape change parameter by modified phospholipids in oxidized LDL
Background: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases. Objective: Identify the active component(s) of oxidized LDL that initiated shape change in p...
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/28197 |
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| Institution: | Mahidol University |
| Summary: | Background: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases. Objective: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human platelets prepared by a gel filtration method. Material and Method: Shape change parameter of platelets was monitored following exposure platelets to LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL. Results: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent manner. Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect. Conclusion: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the active components responsible for changes in platelet function. |
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