Multiple pathways guide oxygen diffusion into flavoenzyme active sites

• Main Authors: Riccardo Baron, Conor Riley, Pirom Chenprakhon, Kittisak Thotsaporn, Remko T. Winter, Andrea Alfieri, Federico Forneris, Willem J.H. Van Berkel, Pimchai Chaiyen, Marco W. Fraaije, Andrea Mattevi, J. Andrew McCammon
• Other Authors: University of California, San Diego
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28389
• Institution: Mahidol University

Dioxygen (O2) and other gas molecules have a fundamental role in a variety of enzymatic reactions. However, it is only poorly understood which O2 uptake mechanism enzymes employ to promote efficient catalysis and how general this is. We investigated O2 diffusion pathways into monooxygenase and oxida...