Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models

• Main Authors: Direk Limmathurotsakul, Kris Jamsen, Arkhom Arayawichanont, Julie A. Simpson, Lisa J. White, Sue J. Lee, Vanaporn Wuthiekanun, Narisara Chantratita, Allen Cheng, Nicholas P.J. Day, Claudio Verzilli, Sharon J. Peacock
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28444

Background: Culture remains the diagnostic gold standard for many bacterial infections, and the method against which other tests are often evaluated. Specificity of culture is 100% if the pathogenic organism is not found in healthy subjects, but the sensitivity of culture is more difficult to determ...