Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy
Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeos...
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th-mahidol.285862018-09-24T16:16:15Z Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy Narisa Futrakul Punnee Butthep Sirichan Chunhakan Wansa Banyatsuppasin Prasit Futrakul Chulalongkorn University Mahidol University Biochemistry, Genetics and Molecular Biology Medicine Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeostasis in twenty patients associated with normo-albuminuric type 2 DN. Results: Angiogenic factors were observed in normo-albuminuric type 2 DN, where vascular endothelial growth factor (VEGF), was 420 ± 341 vs. 428±291 pg/mL (normal), and vascular endothelial growth factor - receptor 1 (VEGF-R1) was 60±12 vs. 49±5 ng/mL (normal), which were not significantly different from the controls. Anti-angiogenic factors were observed in normo-albuminuric type 2 DN, where angiopoietin-2, was 2309±1125 vs. 1671±835 pg/mL (normal), and vascular endothelial growth factor - receptor 2 (VEGF-R2) was 5715±1400 vs.6126 ± 1060 ng/mL (normal), which were not significantly different from the controls. Conclusion: The mechanism of vascular homeostasis was adequately functional in normo-albuminuric type 2 DN. This mechanism may explain the positive response to vasodilators and improved renal function in early stage of type 2 DN following the vasodilator treatment. 2018-09-24T08:41:03Z 2018-09-24T08:41:03Z 2010-12-01 Article Asian Biomedicine. Vol.4, No.6 (2010), 987-990 1875855X 19057415 2-s2.0-84871691748 https://repository.li.mahidol.ac.th/handle/123456789/28586 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871691748&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Narisa Futrakul Punnee Butthep Sirichan Chunhakan Wansa Banyatsuppasin Prasit Futrakul Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
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Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeostasis in twenty patients associated with normo-albuminuric type 2 DN. Results: Angiogenic factors were observed in normo-albuminuric type 2 DN, where vascular endothelial growth factor (VEGF), was 420 ± 341 vs. 428±291 pg/mL (normal), and vascular endothelial growth factor - receptor 1 (VEGF-R1) was 60±12 vs. 49±5 ng/mL (normal), which were not significantly different from the controls. Anti-angiogenic factors were observed in normo-albuminuric type 2 DN, where angiopoietin-2, was 2309±1125 vs. 1671±835 pg/mL (normal), and vascular endothelial growth factor - receptor 2 (VEGF-R2) was 5715±1400 vs.6126 ± 1060 ng/mL (normal), which were not significantly different from the controls. Conclusion: The mechanism of vascular homeostasis was adequately functional in normo-albuminuric type 2 DN. This mechanism may explain the positive response to vasodilators and improved renal function in early stage of type 2 DN following the vasodilator treatment. |
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Chulalongkorn University |
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Chulalongkorn University Narisa Futrakul Punnee Butthep Sirichan Chunhakan Wansa Banyatsuppasin Prasit Futrakul |
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Article |
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Narisa Futrakul Punnee Butthep Sirichan Chunhakan Wansa Banyatsuppasin Prasit Futrakul |
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Narisa Futrakul |
title |
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
title_short |
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
title_full |
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
title_fullStr |
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
title_full_unstemmed |
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
title_sort |
vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/28586 |
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1763488824740020224 |