Protective effect of mangosteen extract against β-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells

• Main Authors: Primchanien Moongkarndi, Chatchawan Srisawat, Putita Saetun, Jiraporn Jantaravinid, Chayanon Peerapittayamongkol, Rungtip Soi-Ampornkul, Sarawut Junnu, Supachok Sinchaikul, Shui Tein Chen, Patcharakajee Charoensilp, Visith Thongboonkerd, Neelobol Neungton
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28714

β-amyloid (Aβ) plays a key role in the pathogenesis of Alzheimers disease (AD) by inducing neurotoxicity and cell death mainly through production of reactive oxygen species (ROS). Garcinia mangostana L. (mangosteen) has been recognized as a major source of natural antioxidants that could decrease RO...