AV<inf>H</inf>H that neutralizes the zinc metalloproteinase activity of botulinum neurotoxin type A

• Main Authors: Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Santi Maneewatch, Kiattawee Choowongkomon, Pramuan Tapchaisri, Sou Ichi Makino, Hisao Kurazono, Wanpen Chaicumpa
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28753

The current treatment of botulism is to administer animal-derived antitoxin, which frequently causes severe adverse reactions in the recipients. In this study, a heavy chain antibody fragment (VH/VHH) phage display library was constructed by amplification of the immunoglobulin genes of a nonimmune c...