Induction of TNF-α in human macrophages by avian and human influenza viruses

• Main Authors: Yuwarat Monteerarat, Saori Sakabe, Somying Ngamurulert, Sirawat Srichatraphimuk, Wasana Jiamtom, Kridsada Chaichuen, Arunee Thitithanyanont, Parichart Permpikul, Taweesak Songserm, Pilaipan Puthavathana, Chairul A. Nidom, Le Quynh Mai, Kiyoko Iwatsuki-Horimoto, Yoshihiro Kawaoka, Prasert Auewarakul
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29218

The highly pathogenic avian influenza virus H5N1 is known to induce high level of tumor necrosis factor α (TNF-α) from primary macrophages. However, it is still unclear whether current H5N1 strains also induce high TNF-α production, as most of the data were derived from extinct clade 0 H5N1 strain....