Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults

House dust mite is a major cause of allergic asthma and rhinitis in Thai population. Skin prick test (SPT) is a useful tool for the diagnosis of the IgE-mediated reactions. The imported commercial mite vaccine for SPT is available but it is relatively expensive. Aim of this studyis to compare Sirira...

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Main Authors: Nualanong Visitsunthorn, Punchama Pacharn, Orathai Jirapongsananuruk, Sirirat Weeravejsukit, Chaweewan Sripramong, Nitat Sookrung, Chaweewan Bunnag
Other Authors: Division of Allergy and Immunology
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/29264
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spelling th-mahidol.292642018-09-24T16:32:43Z Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults Nualanong Visitsunthorn Punchama Pacharn Orathai Jirapongsananuruk Sirirat Weeravejsukit Chaweewan Sripramong Nitat Sookrung Chaweewan Bunnag Division of Allergy and Immunology Office for Research and Development Mahidol University Immunology and Microbiology Medicine House dust mite is a major cause of allergic asthma and rhinitis in Thai population. Skin prick test (SPT) is a useful tool for the diagnosis of the IgE-mediated reactions. The imported commercial mite vaccine for SPT is available but it is relatively expensive. Aim of this studyis to compare Siriraj Mite Allergen Vaccine (SMAV) with standardized commercial mite allergen vaccine by skin prick testing in normal Thai adults. A double blind, self-controlled study between the SMAV and standardized commercial mite allergen vaccine was performed by SPT in 17 normal Thai adult males and non-pregnant or non-lactating females aged 18-60 years. The study showed that 35.29 % of non atopic adults had positive SPT reaction to Dp and Df of both SMAV andstandardized commercial mite allergen vaccine. Mean wheal and flare diameters from SPT of Dp and Df of SMAV showed strong correlation with standardized commercial mite allergen vaccine (r = 0.768 and 0.897 in Dp and Df respectively, p <0.001). The intraclass correlation was also excellent (0.893 and 0.775 in Dp and Df respectively). There was no significant difference in wheal and flare diameter between SMAV andstandardized commercial mite allergen vaccine. No systemic or large local reaction was found in any of the study cases. 2018-09-24T09:07:35Z 2018-09-24T09:07:35Z 2010-03-01 Article Asian Pacific Journal of Allergy and Immunology. Vol.28, No.1 (2010), 41-45 0125877X 2-s2.0-77954543833 https://repository.li.mahidol.ac.th/handle/123456789/29264 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954543833&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
Nualanong Visitsunthorn
Punchama Pacharn
Orathai Jirapongsananuruk
Sirirat Weeravejsukit
Chaweewan Sripramong
Nitat Sookrung
Chaweewan Bunnag
Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
description House dust mite is a major cause of allergic asthma and rhinitis in Thai population. Skin prick test (SPT) is a useful tool for the diagnosis of the IgE-mediated reactions. The imported commercial mite vaccine for SPT is available but it is relatively expensive. Aim of this studyis to compare Siriraj Mite Allergen Vaccine (SMAV) with standardized commercial mite allergen vaccine by skin prick testing in normal Thai adults. A double blind, self-controlled study between the SMAV and standardized commercial mite allergen vaccine was performed by SPT in 17 normal Thai adult males and non-pregnant or non-lactating females aged 18-60 years. The study showed that 35.29 % of non atopic adults had positive SPT reaction to Dp and Df of both SMAV andstandardized commercial mite allergen vaccine. Mean wheal and flare diameters from SPT of Dp and Df of SMAV showed strong correlation with standardized commercial mite allergen vaccine (r = 0.768 and 0.897 in Dp and Df respectively, p <0.001). The intraclass correlation was also excellent (0.893 and 0.775 in Dp and Df respectively). There was no significant difference in wheal and flare diameter between SMAV andstandardized commercial mite allergen vaccine. No systemic or large local reaction was found in any of the study cases.
author2 Division of Allergy and Immunology
author_facet Division of Allergy and Immunology
Nualanong Visitsunthorn
Punchama Pacharn
Orathai Jirapongsananuruk
Sirirat Weeravejsukit
Chaweewan Sripramong
Nitat Sookrung
Chaweewan Bunnag
format Article
author Nualanong Visitsunthorn
Punchama Pacharn
Orathai Jirapongsananuruk
Sirirat Weeravejsukit
Chaweewan Sripramong
Nitat Sookrung
Chaweewan Bunnag
author_sort Nualanong Visitsunthorn
title Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
title_short Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
title_full Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
title_fullStr Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
title_full_unstemmed Comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
title_sort comparison between siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal thai adults
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/29264
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