Superantigens
Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of...
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2018
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th-mahidol.296482018-09-24T16:27:36Z Superantigens Nicholas W. Stow Richard Douglas Pongsakorn Tantilipikorn Jean Silvain Lacroix North Shore Hospital Auckland City Hospital Mahidol University Hopitaux universitaires de Geneve Medicine Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic conditions. The newly described staphylococcal SAg-like proteins subvert innate immune function by several mechanisms, which are distinct from SAgs' effects on lymphocytes and other acquired immune processes. There is mounting evidence to suggest that SAgs play a role in the pathophysiology of inflammatory airway disease. The pathophysiologic role of SAg-like proteins awaits clarification. © 2010 Elsevier Inc. 2018-09-24T09:27:36Z 2018-09-24T09:27:36Z 2010-06-01 Review Otolaryngologic Clinics of North America. Vol.43, No.3 (2010), 489-502 10.1016/j.otc.2010.02.008 00306665 2-s2.0-77953525403 https://repository.li.mahidol.ac.th/handle/123456789/29648 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77953525403&origin=inward |
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Mahidol University |
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Mahidol University Library |
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Asia |
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Thailand Thailand |
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Mahidol University Library |
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Mahidol University Institutional Repository |
| topic |
Medicine |
| spellingShingle |
Medicine Nicholas W. Stow Richard Douglas Pongsakorn Tantilipikorn Jean Silvain Lacroix Superantigens |
| description |
Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic conditions. The newly described staphylococcal SAg-like proteins subvert innate immune function by several mechanisms, which are distinct from SAgs' effects on lymphocytes and other acquired immune processes. There is mounting evidence to suggest that SAgs play a role in the pathophysiology of inflammatory airway disease. The pathophysiologic role of SAg-like proteins awaits clarification. © 2010 Elsevier Inc. |
| author2 |
North Shore Hospital |
| author_facet |
North Shore Hospital Nicholas W. Stow Richard Douglas Pongsakorn Tantilipikorn Jean Silvain Lacroix |
| format |
Review |
| author |
Nicholas W. Stow Richard Douglas Pongsakorn Tantilipikorn Jean Silvain Lacroix |
| author_sort |
Nicholas W. Stow |
| title |
Superantigens |
| title_short |
Superantigens |
| title_full |
Superantigens |
| title_fullStr |
Superantigens |
| title_full_unstemmed |
Superantigens |
| title_sort |
superantigens |
| publishDate |
2018 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/29648 |
| _version_ |
1763492394664198144 |