Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?

Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?

A 34-year-old Thai woman developed acute left hemiparesis with dysarthria from subcortical infarction of the right MCA territory eighteen months after being diagnosed with Noonan syndrome, diabetes mellitus, dyslipidaemia, and hypertension. Further investigations suggested atherosclerosis as a cause...

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Main Authors: Jakris Eu-Ahsunthornwattana, Objoon Trachoo, Donniphat Dejsuphong, Atchara Tunteeratum, Kanoknan Srichan, Thanyachai Sura
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/29818
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spelling th-mahidol.298182018-09-24T16:35:41Z Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution? Jakris Eu-Ahsunthornwattana Objoon Trachoo Donniphat Dejsuphong Atchara Tunteeratum Kanoknan Srichan Thanyachai Sura Mahidol University Medicine A 34-year-old Thai woman developed acute left hemiparesis with dysarthria from subcortical infarction of the right MCA territory eighteen months after being diagnosed with Noonan syndrome, diabetes mellitus, dyslipidaemia, and hypertension. Further investigations suggested atherosclerosis as a cause. Modifying her risk factors was difficult, artly because of limited adherence. Three years later, she had another attack of ischaemic stroke in the same area. Unlike the three previously reported cases, the causation of strokes in this patient appeared to be a more 'complex' interaction between genetic defect and environment including possible subtle arterial abnormalities, metabolic risk factors, and mental insufficiency. 2018-09-24T09:35:41Z 2018-09-24T09:35:41Z 2010-01-01 Article Journal of the Medical Association of Thailand. Vol.93, No.9 (2010), 1084-1087 01252208 01252208 2-s2.0-77958036623 https://repository.li.mahidol.ac.th/handle/123456789/29818 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77958036623&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Jakris Eu-Ahsunthornwattana
Objoon Trachoo
Donniphat Dejsuphong
Atchara Tunteeratum
Kanoknan Srichan
Thanyachai Sura
Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
description A 34-year-old Thai woman developed acute left hemiparesis with dysarthria from subcortical infarction of the right MCA territory eighteen months after being diagnosed with Noonan syndrome, diabetes mellitus, dyslipidaemia, and hypertension. Further investigations suggested atherosclerosis as a cause. Modifying her risk factors was difficult, artly because of limited adherence. Three years later, she had another attack of ischaemic stroke in the same area. Unlike the three previously reported cases, the causation of strokes in this patient appeared to be a more 'complex' interaction between genetic defect and environment including possible subtle arterial abnormalities, metabolic risk factors, and mental insufficiency.
author2 Mahidol University
author_facet Mahidol University
Jakris Eu-Ahsunthornwattana
Objoon Trachoo
Donniphat Dejsuphong
Atchara Tunteeratum
Kanoknan Srichan
Thanyachai Sura
format Article
author Jakris Eu-Ahsunthornwattana
Objoon Trachoo
Donniphat Dejsuphong
Atchara Tunteeratum
Kanoknan Srichan
Thanyachai Sura
author_sort Jakris Eu-Ahsunthornwattana
title Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
title_short Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
title_full Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
title_fullStr Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
title_full_unstemmed Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
title_sort noonan syndrome, metabolic syndrome and stroke-in-the-young: coincidence, causal or contribution?
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/29818
_version_ 1763492107997151232

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