Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat
The effect of adrenalectomy on the basal cardiac c-AMP level and the elevated c-AMP level induced by intravenous administration of isoprenaline (10 mcg/kg) were determined by radio-protein assay. The basal cardiac c-AMP level was not altered by adrenalectomy. But the cardiac c-AMP responses to isopr...
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th-mahidol.303002018-10-12T14:28:24Z Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat S. Phornchirasilp O. P. Matangkasombut Mahidol University Biochemistry, Genetics and Molecular Biology Medicine The effect of adrenalectomy on the basal cardiac c-AMP level and the elevated c-AMP level induced by intravenous administration of isoprenaline (10 mcg/kg) were determined by radio-protein assay. The basal cardiac c-AMP level was not altered by adrenalectomy. But the cardiac c-AMP responses to isoprenaline were significantly less in adrenalectomized rats, maintained with 1% sodium chloride solution for one week; this effect, however, disappeared when animals were maintained for 2 or 4 weeks. This could not be restored by acute administration of dexamethasone (100 mcg/rat). The possible reasons for these effects of adrenalectomy are discussed. 2018-10-12T07:25:41Z 2018-10-12T07:25:41Z 1982-01-01 Article Hormone and Metabolic Research. Vol.14, No.4 (1982), 207-209 10.1055/s-2007-1018970 00185043 2-s2.0-0020036297 https://repository.li.mahidol.ac.th/handle/123456789/30300 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020036297&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine S. Phornchirasilp O. P. Matangkasombut Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
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The effect of adrenalectomy on the basal cardiac c-AMP level and the elevated c-AMP level induced by intravenous administration of isoprenaline (10 mcg/kg) were determined by radio-protein assay. The basal cardiac c-AMP level was not altered by adrenalectomy. But the cardiac c-AMP responses to isoprenaline were significantly less in adrenalectomized rats, maintained with 1% sodium chloride solution for one week; this effect, however, disappeared when animals were maintained for 2 or 4 weeks. This could not be restored by acute administration of dexamethasone (100 mcg/rat). The possible reasons for these effects of adrenalectomy are discussed. |
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Mahidol University |
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Mahidol University S. Phornchirasilp O. P. Matangkasombut |
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Article |
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S. Phornchirasilp O. P. Matangkasombut |
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S. Phornchirasilp |
title |
Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
title_short |
Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
title_full |
Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
title_fullStr |
Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
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Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat |
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role of adrenal steroids on the cardiac c-amp response to isoprenaline in the rat |
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2018 |
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