Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease
The plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were hig...
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th-mahidol.303922018-10-12T14:28:09Z Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease S. Vatanavicharn P. Pringsulka S. Kritalugsana P. Phuapairoj P. Wasi Mahidol University Medicine The plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were higher in the patients than in controls. The plasma Cu:Zn ratios, a more valuable indicator of body zinc status, increased in the diseased subjects, indicating zinc deficiency. Higher urinary zinc levels in the both Hb H disease and β-thalassemia/Hb E disease suggest that chronic hemolysis is responsible for hyperzincuria leading to zinc deficiency. The thalassemic patients with undergrowth had higher plasma Cu:Zn ratios than the patients with normal development, indicating a more severe zinc deficiency in the former. 2018-10-12T07:28:09Z 2018-10-12T07:28:09Z 1982-01-01 Article Acta Haematologica. Vol.68, No.4 (1982), 317-320 10.1159/000207000 00015792 2-s2.0-0020454895 https://repository.li.mahidol.ac.th/handle/123456789/30392 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020454895&origin=inward |
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Medicine S. Vatanavicharn P. Pringsulka S. Kritalugsana P. Phuapairoj P. Wasi Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
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The plasma zinc and copper and urinary zinc levels were determined by an atomic absorption spectrophotometer technic in 14 patients with hemoglobin (Hb) H disease, 34 patients with β-thalassemia/Hb E disease and 30 control subjects. Plasma zinc levels were lower and the plasma copper levels were higher in the patients than in controls. The plasma Cu:Zn ratios, a more valuable indicator of body zinc status, increased in the diseased subjects, indicating zinc deficiency. Higher urinary zinc levels in the both Hb H disease and β-thalassemia/Hb E disease suggest that chronic hemolysis is responsible for hyperzincuria leading to zinc deficiency. The thalassemic patients with undergrowth had higher plasma Cu:Zn ratios than the patients with normal development, indicating a more severe zinc deficiency in the former. |
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Mahidol University |
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Mahidol University S. Vatanavicharn P. Pringsulka S. Kritalugsana P. Phuapairoj P. Wasi |
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Article |
author |
S. Vatanavicharn P. Pringsulka S. Kritalugsana P. Phuapairoj P. Wasi |
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S. Vatanavicharn |
title |
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
title_short |
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
title_full |
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
title_fullStr |
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
title_full_unstemmed |
Zinc and copper status in hemoglobin H disease and β-thalassemia/hemoglobin E disease |
title_sort |
zinc and copper status in hemoglobin h disease and β-thalassemia/hemoglobin e disease |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/30392 |
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1763495850946854912 |