Studies on aristolochia III. isolation and biological evaluation of constituents of aristolochia indica roots for fertility-regulating activity¹

• Main Authors: Mohamed S. Ahmed, Sam S. Kang, Pathmanayaki Rajamahendran, Nuntavan Bunyapraphatsara, R. O.B. Wijesekera, Chun Tao Che, Donald P. Waller, A. S. Bingel, Annamarie Martin, David C. Lankin, Geoffrey A. Cordell, Djaja D. Soejarto, Harry H.S. Fong
• Other Authors: Cairo University Faculty of Pharmacy
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/30592
• Institution: Mahidol University

ethanol extract of Aristolochia indica roots decreased fertility in both rats and hamsters when administered postcoitally (days 1-10 and 1-6, respectively). Petroleum ether (A), CHCl3(B), and aqueous (C) fractions, tested similarly in rats, were inactive and/or toxic. Partition of fraction B afforded non-acidic (D) and acidic (E) fractions. Savinin (1), isolated from fraction D and not previously reported from the Aristolochiaceae, was inactive when administered postcoitally to rats. Aristolochic acid-I (2), reported previously from A. indica and isolated from fraction E, was inactive when administered postcoitally to rats and toxic when administered postcoitally to hamsters. © 1984, American Chemical Society. All rights reserved.