A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures

In a pilot control project with Opisthorchis viverrini in the village of Nong Wai Irrigation Area, Khon Kaen, Northeast Thailand, selected population based chemotherapy with a single dose of 40 mg/kg of praziquantel ((2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinol in-4-one,...

Full description

Saved in:
Bibliographic Details
Main Authors: S. Sornmani, F. P. Schelp, P. Vivatanasesth, W. Patihatakorn, P. Impand, P. Sitabutra, P. Worasan, S. Preuksaraj
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/30595
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.30595
record_format dspace
spelling th-mahidol.305952018-10-12T14:44:36Z A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures S. Sornmani F. P. Schelp P. Vivatanasesth W. Patihatakorn P. Impand P. Sitabutra P. Worasan S. Preuksaraj Mahidol University Chemistry Pharmacology, Toxicology and Pharmaceutics In a pilot control project with Opisthorchis viverrini in the village of Nong Wai Irrigation Area, Khon Kaen, Northeast Thailand, selected population based chemotherapy with a single dose of 40 mg/kg of praziquantel ((2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinol in-4-one, EMBAY 8440, Biltricide®) was given to the stool positive cases once a year for a period of 3 years commencing in May 1981. Two villages (pop. 942) with a prevalence of 58.3% were used as test villages and another one (pop. 442) with a prevalence of 55.1% served as a control. The project programme integrated chemotherapy, sanitation improvement and health education, whilst only chemotherapy was applied in the control village. Among the 736 cases of all villages, 666 were treated in the first year and the parasitological cure rate after 1 month was 95.9%. Side effects of praziquantel were minor and were minimized by changing the time of drug intake from morning to after dinner. After 1 year the prevalence of opisthorchiasis was 36.8% in the test villages and 54.8% in the control village. The study on re-infection rate revealed that the average monthly incidence rate among the population in the test villages was 2.0% per month (range 1.1-5.0%) whereas it was 5.0% per month (range 1.9-10.3%) in the control village. In May 1982, a second treatment was given to the positive cases in the 3 villages with the same dose. The second year evaluation is in progress. 2018-10-12T07:40:55Z 2018-10-12T07:40:55Z 1984-11-29 Article Arzneimittel-Forschung/Drug Research. Vol.34, No.9 B (1984), 1231-1234 00044172 2-s2.0-0021166933 https://repository.li.mahidol.ac.th/handle/123456789/30595 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0021166933&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemistry
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Chemistry
Pharmacology, Toxicology and Pharmaceutics
S. Sornmani
F. P. Schelp
P. Vivatanasesth
W. Patihatakorn
P. Impand
P. Sitabutra
P. Worasan
S. Preuksaraj
A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
description In a pilot control project with Opisthorchis viverrini in the village of Nong Wai Irrigation Area, Khon Kaen, Northeast Thailand, selected population based chemotherapy with a single dose of 40 mg/kg of praziquantel ((2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinol in-4-one, EMBAY 8440, Biltricide®) was given to the stool positive cases once a year for a period of 3 years commencing in May 1981. Two villages (pop. 942) with a prevalence of 58.3% were used as test villages and another one (pop. 442) with a prevalence of 55.1% served as a control. The project programme integrated chemotherapy, sanitation improvement and health education, whilst only chemotherapy was applied in the control village. Among the 736 cases of all villages, 666 were treated in the first year and the parasitological cure rate after 1 month was 95.9%. Side effects of praziquantel were minor and were minimized by changing the time of drug intake from morning to after dinner. After 1 year the prevalence of opisthorchiasis was 36.8% in the test villages and 54.8% in the control village. The study on re-infection rate revealed that the average monthly incidence rate among the population in the test villages was 2.0% per month (range 1.1-5.0%) whereas it was 5.0% per month (range 1.9-10.3%) in the control village. In May 1982, a second treatment was given to the positive cases in the 3 villages with the same dose. The second year evaluation is in progress.
author2 Mahidol University
author_facet Mahidol University
S. Sornmani
F. P. Schelp
P. Vivatanasesth
W. Patihatakorn
P. Impand
P. Sitabutra
P. Worasan
S. Preuksaraj
format Article
author S. Sornmani
F. P. Schelp
P. Vivatanasesth
W. Patihatakorn
P. Impand
P. Sitabutra
P. Worasan
S. Preuksaraj
author_sort S. Sornmani
title A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
title_short A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
title_full A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
title_fullStr A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
title_full_unstemmed A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures
title_sort pilot project for controlling o. viverrini infection in nong wai, northeast thailand, by applying praziquantel and other measures
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/30595
_version_ 1763489483047567360