A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria

• Main Authors: Panote Prapansilp, Isabelle Medana, Nguyen Thi Hoan Mai, Day, Nicholas PJ, Phu, Nguyen Hoan, Yeo, Tsin W, Hien, Tran Tinh, Nicholas J White, Anstey, Nicholas M, Turner, Gareth DH
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
• Format: Research Report
• Language: English
• Published: 2017
• Subjects: Open Access article; Malaria; Human; Plasmodium falciparum; Pathogenesis; Pathology; Cerebral; Angiopoietin; Tie-2 receptor; Immunohistochemistry; Biomarker; Blood brain barrier
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3066
• Institution: Mahidol University

Background: Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. However the mechanism of action of the angiopoietins in fatal malaria is unclear. This study aimed to determine whether the expression of Ang-1 and Ang-2 and th...